U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Flu-Like Symptoms

MedGen UID:
140262
•Concept ID:
C0392171
•
Sign or Symptom
Synonyms: ILI; Influenza-Like Illness

Definition

Complaints describing a pattern similar to influenza, which may include one or more of the following symptoms: fever, chills, muscle or body aches, cough, sore throat, rhinitis, or fatigue. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFlu-Like Symptoms

Professional guidelines

PubMed

COVID-19 Transmission, Current Treatment, and Future Therapeutic Strategies.
Salian VS, Wright JA, Vedell PT, Nair S, Li C, Kandimalla M, Tang X, Carmona Porquera EM, Kalari KR, Kandimalla KK
Mol Pharm 2021 Mar 1;18(3):754-771. Epub 2021 Jan 19 doi: 10.1021/acs.molpharmaceut.0c00608. PMID: 33464914
Brucella - Virulence Factors, Pathogenesis and Treatment.
Głowacka P, Żakowska D, Naylor K, Niemcewicz M, Bielawska-Drózd A
Pol J Microbiol 2018 Jun 30;67(2):151-161. doi: 10.21307/pjm-2018-029. PMID: 30015453Free PMC Article
EUROPAEM EMF Guideline 2016 for the prevention, diagnosis and treatment of EMF-related health problems and illnesses.
Belyaev I, Dean A, Eger H, Hubmann G, Jandrisovits R, Kern M, Kundi M, Moshammer H, Lercher P, Müller K, Oberfeld G, Ohnsorge P, Pelzmann P, Scheingraber C, Thill R
Rev Environ Health 2016 Sep 1;31(3):363-97. doi: 10.1515/reveh-2016-0011. PMID: 27454111

Recent clinical studies

Etiology

Transcutaneous Auricular Vagus Nerve Stimulation (ta-VNS) for Treatment of Drug-Resistant Epilepsy: A Randomized, Double-Blind Clinical Trial.
Yang H, Shi W, Fan J, Wang X, Song Y, Lian Y, Shan W, Wang Q
Neurotherapeutics 2023 Apr;20(3):870-880. Epub 2023 Mar 30 doi: 10.1007/s13311-023-01353-9. PMID: 36995682Free PMC Article
A Rational Use of Clozapine Based on Adverse Drug Reactions, Pharmacokinetics, and Clinical Pharmacopsychology.
de Leon J, Ruan CJ, Schoretsanitis G, De Las Cuevas C
Psychother Psychosom 2020;89(4):200-214. Epub 2020 Apr 14 doi: 10.1159/000507638. PMID: 32289791Free PMC Article
Mipomersen and its use in familial hypercholesterolemia.
Parham JS, Goldberg AC
Expert Opin Pharmacother 2019 Feb;20(2):127-131. Epub 2018 Dec 10 doi: 10.1080/14656566.2018.1550071. PMID: 30526168Free PMC Article
Infectious endocarditis: An update for emergency clinicians.
Long B, Koyfman A
Am J Emerg Med 2018 Sep;36(9):1686-1692. Epub 2018 Jul 2 doi: 10.1016/j.ajem.2018.06.074. PMID: 30001813
Antidepressant discontinuation syndrome.
Warner CH, Bobo W, Warner C, Reid S, Rachal J
Am Fam Physician 2006 Aug 1;74(3):449-56. PMID: 16913164

Diagnosis

Cutaneous Coccidiomycosis.
Brown M, Zhou AE, Jaffe DF, Pfau RG
Am J Dermatopathol 2024 Feb 1;46(2):111-113. Epub 2023 Dec 6 doi: 10.1097/DAD.0000000000002601. PMID: 38055960
Pulmonary pathology of ARDS in COVID-19: A pathological review for clinicians.
Batah SS, Fabro AT
Respir Med 2021 Jan;176:106239. Epub 2020 Nov 19 doi: 10.1016/j.rmed.2020.106239. PMID: 33246294Free PMC Article
New onset refractory status epilepticus (NORSE).
Sculier C, Gaspard N
Seizure 2019 May;68:72-78. Epub 2018 Sep 29 doi: 10.1016/j.seizure.2018.09.018. PMID: 30482654
EUROPAEM EMF Guideline 2016 for the prevention, diagnosis and treatment of EMF-related health problems and illnesses.
Belyaev I, Dean A, Eger H, Hubmann G, Jandrisovits R, Kern M, Kundi M, Moshammer H, Lercher P, Müller K, Oberfeld G, Ohnsorge P, Pelzmann P, Scheingraber C, Thill R
Rev Environ Health 2016 Sep 1;31(3):363-97. doi: 10.1515/reveh-2016-0011. PMID: 27454111
Chikungunya virus infection: an overview.
Caglioti C, Lalle E, Castilletti C, Carletti F, Capobianchi MR, Bordi L
New Microbiol 2013 Jul;36(3):211-27. Epub 2013 Jun 30 PMID: 23912863

Therapy

Feasibility and impact of ketogenic dietary interventions in polycystic kidney disease: KETO-ADPKD-a randomized controlled trial.
Cukoski S, Lindemann CH, Arjune S, Todorova P, Brecht T, Kühn A, Oehm S, Strubl S, Becker I, Kämmerer U, Torres JA, Meyer F, Schömig T, Hokamp NG, Siedek F, Gottschalk I, Benzing T, Schmidt J, Antczak P, Weimbs T, Grundmann F, Müller RU
Cell Rep Med 2023 Nov 21;4(11):101283. Epub 2023 Nov 7 doi: 10.1016/j.xcrm.2023.101283. PMID: 37935200Free PMC Article
ALT-803, an IL-15 superagonist, in combination with nivolumab in patients with metastatic non-small cell lung cancer: a non-randomised, open-label, phase 1b trial.
Wrangle JM, Velcheti V, Patel MR, Garrett-Mayer E, Hill EG, Ravenel JG, Miller JS, Farhad M, Anderton K, Lindsey K, Taffaro-Neskey M, Sherman C, Suriano S, Swiderska-Syn M, Sion A, Harris J, Edwards AR, Rytlewski JA, Sanders CM, Yusko EC, Robinson MD, Krieg C, Redmond WL, Egan JO, Rhode PR, Jeng EK, Rock AD, Wong HC, Rubinstein MP
Lancet Oncol 2018 May;19(5):694-704. Epub 2018 Apr 5 doi: 10.1016/S1470-2045(18)30148-7. PMID: 29628312Free PMC Article
An open label, single-arm, phase II multicenter study of the safety and efficacy of CG0070 oncolytic vector regimen in patients with BCG-unresponsive non-muscle-invasive bladder cancer: Interim results.
Packiam VT, Lamm DL, Barocas DA, Trainer A, Fand B, Davis RL 3rd, Clark W, Kroeger M, Dumbadze I, Chamie K, Kader AK, Curran D, Gutheil J, Kuan A, Yeung AW, Steinberg GD
Urol Oncol 2018 Oct;36(10):440-447. Epub 2017 Jul 26 doi: 10.1016/j.urolonc.2017.07.005. PMID: 28755959
Fluoropolymer-associated illness.
Hays HL, Spiller H
Clin Toxicol (Phila) 2014 Sep-Oct;52(8):848-55. doi: 10.3109/15563650.2014.946610. PMID: 25200453
Antidepressant discontinuation syndrome.
Warner CH, Bobo W, Warner C, Reid S, Rachal J
Am Fam Physician 2006 Aug 1;74(3):449-56. PMID: 16913164

Prognosis

COVID-19 and cardiovascular manifestations.
Parvu S, Müller K, Dahdal D, Cosmin I, Christodorescu R, Duda-Seiman D, Man D, Sharma A, Dragoi R, Baneu P, Dragan S
Eur Rev Med Pharmacol Sci 2022 Jun;26(12):4509-4519. doi: 10.26355/eurrev_202206_29090. PMID: 35776052
COVID-19 and diabetes: Knowledge in progress.
Hussain A, Bhowmik B, do Vale Moreira NC
Diabetes Res Clin Pract 2020 Apr;162:108142. Epub 2020 Apr 9 doi: 10.1016/j.diabres.2020.108142. PMID: 32278764Free PMC Article
Prediction models for diagnosis and prognosis of covid-19: systematic review and critical appraisal.
Wynants L, Van Calster B, Collins GS, Riley RD, Heinze G, Schuit E, Bonten MMJ, Dahly DL, Damen JAA, Debray TPA, de Jong VMT, De Vos M, Dhiman P, Haller MC, Harhay MO, Henckaerts L, Heus P, Kammer M, Kreuzberger N, Lohmann A, Luijken K, Ma J, Martin GP, McLernon DJ, Andaur Navarro CL, Reitsma JB, Sergeant JC, Shi C, Skoetz N, Smits LJM, Snell KIE, Sperrin M, Spijker R, Steyerberg EW, Takada T, Tzoulaki I, van Kuijk SMJ, van Bussel B, van der Horst ICC, van Royen FS, Verbakel JY, Wallisch C, Wilkinson J, Wolff R, Hooft L, Moons KGM, van Smeden M
BMJ 2020 Apr 7;369:m1328. doi: 10.1136/bmj.m1328. PMID: 32265220Free PMC Article
New onset refractory status epilepticus (NORSE).
Sculier C, Gaspard N
Seizure 2019 May;68:72-78. Epub 2018 Sep 29 doi: 10.1016/j.seizure.2018.09.018. PMID: 30482654
An open label, single-arm, phase II multicenter study of the safety and efficacy of CG0070 oncolytic vector regimen in patients with BCG-unresponsive non-muscle-invasive bladder cancer: Interim results.
Packiam VT, Lamm DL, Barocas DA, Trainer A, Fand B, Davis RL 3rd, Clark W, Kroeger M, Dumbadze I, Chamie K, Kader AK, Curran D, Gutheil J, Kuan A, Yeung AW, Steinberg GD
Urol Oncol 2018 Oct;36(10):440-447. Epub 2017 Jul 26 doi: 10.1016/j.urolonc.2017.07.005. PMID: 28755959

Clinical prediction guides

Transcutaneous Auricular Vagus Nerve Stimulation (ta-VNS) for Treatment of Drug-Resistant Epilepsy: A Randomized, Double-Blind Clinical Trial.
Yang H, Shi W, Fan J, Wang X, Song Y, Lian Y, Shan W, Wang Q
Neurotherapeutics 2023 Apr;20(3):870-880. Epub 2023 Mar 30 doi: 10.1007/s13311-023-01353-9. PMID: 36995682Free PMC Article
COVID-19 and cardiovascular manifestations.
Parvu S, Müller K, Dahdal D, Cosmin I, Christodorescu R, Duda-Seiman D, Man D, Sharma A, Dragoi R, Baneu P, Dragan S
Eur Rev Med Pharmacol Sci 2022 Jun;26(12):4509-4519. doi: 10.26355/eurrev_202206_29090. PMID: 35776052
COVID-19 and diabetes: Knowledge in progress.
Hussain A, Bhowmik B, do Vale Moreira NC
Diabetes Res Clin Pract 2020 Apr;162:108142. Epub 2020 Apr 9 doi: 10.1016/j.diabres.2020.108142. PMID: 32278764Free PMC Article
Prediction models for diagnosis and prognosis of covid-19: systematic review and critical appraisal.
Wynants L, Van Calster B, Collins GS, Riley RD, Heinze G, Schuit E, Bonten MMJ, Dahly DL, Damen JAA, Debray TPA, de Jong VMT, De Vos M, Dhiman P, Haller MC, Harhay MO, Henckaerts L, Heus P, Kammer M, Kreuzberger N, Lohmann A, Luijken K, Ma J, Martin GP, McLernon DJ, Andaur Navarro CL, Reitsma JB, Sergeant JC, Shi C, Skoetz N, Smits LJM, Snell KIE, Sperrin M, Spijker R, Steyerberg EW, Takada T, Tzoulaki I, van Kuijk SMJ, van Bussel B, van der Horst ICC, van Royen FS, Verbakel JY, Wallisch C, Wilkinson J, Wolff R, Hooft L, Moons KGM, van Smeden M
BMJ 2020 Apr 7;369:m1328. doi: 10.1136/bmj.m1328. PMID: 32265220Free PMC Article
Chikungunya virus infection: an overview.
Caglioti C, Lalle E, Castilletti C, Carletti F, Capobianchi MR, Bordi L
New Microbiol 2013 Jul;36(3):211-27. Epub 2013 Jun 30 PMID: 23912863

Recent systematic reviews

Propionyl-L-carnitine for intermittent claudication.
Kamoen V, Vander Stichele R, Campens L, De Bacquer D, Van Bortel L, de Backer TL
Cochrane Database Syst Rev 2021 Dec 26;12(12):CD010117. doi: 10.1002/14651858.CD010117.pub2. PMID: 34954832Free PMC Article
Vaccine-induced immune thrombotic thrombocytopenia and cerebral venous sinus thrombosis post COVID-19 vaccination; a systematic review.
Sharifian-Dorche M, Bahmanyar M, Sharifian-Dorche A, Mohammadi P, Nomovi M, Mowla A
J Neurol Sci 2021 Sep 15;428:117607. Epub 2021 Aug 3 doi: 10.1016/j.jns.2021.117607. PMID: 34365148Free PMC Article
Interventions for mycosis fungoides.
Valipour A, Jäger M, Wu P, Schmitt J, Bunch C, Weberschock T
Cochrane Database Syst Rev 2020 Jul 7;7(7):CD008946. doi: 10.1002/14651858.CD008946.pub3. PMID: 32632956Free PMC Article
Prediction models for diagnosis and prognosis of covid-19: systematic review and critical appraisal.
Wynants L, Van Calster B, Collins GS, Riley RD, Heinze G, Schuit E, Bonten MMJ, Dahly DL, Damen JAA, Debray TPA, de Jong VMT, De Vos M, Dhiman P, Haller MC, Harhay MO, Henckaerts L, Heus P, Kammer M, Kreuzberger N, Lohmann A, Luijken K, Ma J, Martin GP, McLernon DJ, Andaur Navarro CL, Reitsma JB, Sergeant JC, Shi C, Skoetz N, Smits LJM, Snell KIE, Sperrin M, Spijker R, Steyerberg EW, Takada T, Tzoulaki I, van Kuijk SMJ, van Bussel B, van der Horst ICC, van Royen FS, Verbakel JY, Wallisch C, Wilkinson J, Wolff R, Hooft L, Moons KGM, van Smeden M
BMJ 2020 Apr 7;369:m1328. doi: 10.1136/bmj.m1328. PMID: 32265220Free PMC Article
Oral antifungal medication for toenail onychomycosis.
Kreijkamp-Kaspers S, Hawke K, Guo L, Kerin G, Bell-Syer SE, Magin P, Bell-Syer SV, van Driel ML
Cochrane Database Syst Rev 2017 Jul 14;7(7):CD010031. doi: 10.1002/14651858.CD010031.pub2. PMID: 28707751Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...